Microsomal Triglyceride Transfer Protein (MTP)

Microsomal triglyceride transfer protein (MTP) is a heterodimer chaperone consisting of a 97-kDa lipid-binding and -transfer subunit and a 55-kDa protein disulfide isomerase (PDI). MTP was first identified as an endoplasmic reticulum (ER) resident protein that helps in the transfer of neutral lipids to nascent apolipoprotein B (apoB). MTP is predominantly expressed in hepatocytes and enterocytes and is required for the assembly and secretion of VLDL and chylomicrons by the liver and intestine, respectivel. Its critical role in the assembly and secretion of apoB-containing lipoproteins was identified in abetalipoproteinemia patients who have mutations in MTP and completely lack apoB-containing lipoproteins in the circulation. It has been established now that MTP not only is involved in the transfer of neutral lipids but also plays a role in cholesterol ester and cluster of differentiation 1d (CD1d) biosynthesis. Besides neutral lipids, MTP may also help in the transfer of sphingolipids such as ceramides and sphingomyelin to the apoB-containing lipoproteins.

Microsomal Triglyceride Transfer Protein (MTP) Inhibitors (9)

Microsomal Triglyceride Transfer Protein (MTP) Related Products (18):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-14667

Lomitapide	Inhibitor	99.63%
Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC₅₀ of 8 nM in vitro.

HY-14668

Lomitapide mesylate	Inhibitor	99.61%
Lomitapide (AEGR-733; BMS-201038) mesylate is an orally active microsomal triglyceride transfer protein (MTP) inhibitor and a selective mTORC1 inhibitor with lipid-lowering activity and BBB permeability. Lomitapide mesylate significantly reduces plasma LDL levels by blocking the assembly and secretion of very-low-density lipoprotein (VLDL). Lomitapide mesylate inhibits mTORC1 in an ATP-dependent manner, thereby inducing AMPK-independent autophagic cell death and suppressing cancer cell growth and apoptosis. Lomitapide mesylate also enhances tumor infiltration of CD8⁺ T cells. In addition, Lomitapide mesylate inhibits HDAC, improves endothelial function, effectively alleviates vascular inflammation and oxidative stress, and exerts neuroprotective effects in a cerebral ischemia/reperfusion injury model. Lomitapide mesylate can be used in research on related diseases such as colorectal cancer, breast cancer, melanoma, ischemic stroke, and familial hypercholesterolemia.

HY-113955

CP-346086		99.18%
CP-346086 is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC₅₀ of 2.0 nM for human and rodent MTP. CP-346086 can lower plasma cholesterol and triglycerides in vivo.

HY-106011

SLX-4090	Inhibitor	98.97%
SLX-4090 is an orally active enterocytic-specific microsomal triglyceride transfer protein (MTP) inhibitor with an IC₅₀ of 8.0 nM. SLX-4090 can be used for the research of dyslipidemia.

HY-106130

Implitapide		99.87%
Implitapide (AEGR 427) is a microsomal triglyceride transfer protein (MTP) inhibitor.

HY-116630

Usistapide	Inhibitor
Usistapide (JNJ-16269110) is a microsomal triglyceride transfer protein (MTP) inhibitor. Usistapide is promising for research of obesity.

HY-100333

PF-02575799		99.52%
PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC₅₀ of 0.77±0.29 nM.

HY-U00070

Dirlotapide		99.86%
Dirlotapide (CP742033) is a gut-selective inhibitor of microsomal triglyceride transfer protein (MTP) that reliably produces weight loss in obese dogs.

HY-177291

LAB687	Inhibitor
LAB687 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC₅₀ of 0.9 nM for apolipoprotein B (apoB) secretion in HepG2 cells. LAB687 also acts as a Smoothened (Smo) antagonist, with IC₅₀ values of 2.48 μM and 3.42 μM against mouse and human Smo receptors, respectively. LAB687 reduces triglyceride and low-density lipoprotein cholesterol (LDL-C) levels, and inhibits the Hedgehog signaling pathway. LAB687 can be used in studies related to Hedgehog-dependent cancers.

HY-113955A

CP-346086 dihydrate
CP-346086 dihydrate is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC₅₀ of 2.0 nM for human and rodent MTP. CP-346086 dihydrate can lower plasma cholesterol and triglycerides in vivo.

HY-106130R

Implitapide (Standard)
Implitapide (Standard) is the analytical standard of Implitapide (HY-106130). This product is intended for research and analytical applications. Implitapide (AEGR 427) is a microsomal triglyceride transfer protein (MTP) inhibitor.

HY-14667S1

Lomitapide-d₄	Inhibitor
Lomitapide-d₄ (AEGR-733-d₄) is deuterium labeled Lomitapide. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC₅₀ of 8 nM in vitro.

HY-14667R

Lomitapide (Standard)	Inhibitor
Lomitapide (Standard) is the analytical standard of Lomitapide. This product is intended for research and analytical applications. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.

HY-106011R

SLX-4090 (Standard)	Inhibitor
SLX-4090 (Standard) is the analytical standard of SLX-4090 (HY-106011). This product is intended for research and analytical applications. SLX-4090 is an orally active enterocytic-specific microsomal triglyceride transfer protein (MTP) inhibitor with an IC₅₀ of 8.0 nM. SLX-4090 can be used for the research of dyslipidemia.

HY-119220

Granotapide	Inhibitor
Granotapide is an orally active microsomal triglyceride transfer protein (MTP) inhibitor. Granotapide reduces the absorption of cholesterol and triglycerides by inhibiting MTP. Granotapide can be used in the research of coronary artery disease, obesity, diabetes mellitus and hypertension.

HY-14668R

Lomitapide mesylate (Standard)
Lomitapide (mesylate) (Standard) is the analytical standard of Lomitapide (mesylate). This product is intended for research and analytical applications. Lomitapide (AEGR-733; BMS-201038) mesylate is a highly effective MTP protein inhibitor with an in vitro IC50 value of 8nM.

HY-U00329

Implitapide Racemate
Implitapide Racemate is the racemate of Implitapide. Implitapide is a microsomal triglyceride transfer protein (MTP) inhibitor.

HY-U00270

CP-319340free base
CP-319340 free base is a microsomal triglyceride transfer protein (MTP) inhibitor.

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